Small-molecule modulation of β-arrestins
Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10683-5Integrated pharmacological, biochemical, biophysical and structural analyses of small-mole
Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10683-5
Integrated pharmacological, biochemical, biophysical and structural analyses of small-molecule β-arrestin inhibitors show how they block β-arrestin engagement with activated GPCRs, revealing their mechanism of action and uncovering a previously unrecognized allosteric regulatory site.
Fonte original:
https://www.nature.com/articles/s41586-026-10683-5
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