Liquid ripples rewrite 130-year-old biological classic: New reflections on the lock-and-key model

This April, when the spring breeze carried the formal acceptance notice of our paper by the Journal of the American Chemical Society to my desk, my thoughts instantly drifted back to the late Phil Geissler. A legendary physical chemist and the original spark for this research, Geissler had once observed a baffling phenomenon: When the hairy, flexible ligands passivating a nanoparticle's surface spontaneously order themselves into crystalline patterns, a massive, seemingly magical attractive force suddenly erupts between the particles.