Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

24 de junho de 2026 1 min de leitura 6 visualizações Fonte original

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-zChronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-z

Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.

Fonte original: https://www.nature.com/articles/s41586-026-10697-z

Comentários

Seja o primeiro a comentar!

Entre na sua conta para comentar.

Entrar Criar conta

Leia também

Metal hydride molecule trapped with laser light opens path to ultracold hydrogen

Geral EN

Metal hydride molecule trapped with laser light opens path to ultracold hydrogen

Controlling and trapping molecules, units of a substance consisting of two or more chemically bound atoms, with laser light is significantly more challenging th

26 de jun. 1 min

It’s the last day of Prime Day — here are over 130 great deals to choose from

Geral EN

It’s the last day of Prime Day — here are over 130 great deals to choose from

We’ve arrived at the final day of Prime Day, which at this point should probably be called “Prime Week.” We’ve found discounts on all manner of gadgets, includi

26 de jun. 41 min

Samsung will soon start charging to access its smart home API

Geral EN

Samsung will soon start charging to access its smart home API

From October this year Samsung will roll out a variety of new paid tiers for access to its SmartThings API, including a $4.99 monthly plan for "non-commercial,

26 de jun. 1 min

Study challenges idea that simply playing sports makes kids less prone to violent behavior

Geral EN

Study challenges idea that simply playing sports makes kids less prone to violent behavior

Contrary to popular belief, simply playing organized youth sports does not reduce the likelihood of committing violence in one's lifetime and, in some cases, ma

26 de jun. 1 min

Próxima notícia

24 de jun. de 2026

Slate Auto's truck builder goes live for its $25k electric pickup

Fique por dentro das notícias

Receba os melhores conteúdos diretamente no seu e-mail.

💡 Sugestões